Pyrophosphate Metabolism in Liver Mitochondria
نویسندگان
چکیده
منابع مشابه
Ca2+-induced accumulation of pyrophosphate in mitochondria during acetate metabolism.
The mechanism of pyrophosphate (PPi) accumulation in rat liver during acetate metabolism was investigated. Perfusion of the liver with acetate in the presence of noradrenaline and glucagon induced marked accumulation of PPi (2 mumol/g of liver, 200 times that of control). In contrast, perfusion with glutamine, which generates PPi only in the cytosol, caused little accumulation of PPi, even in t...
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The formation of large amounts of inorganic pyrophosphate as a by-product of numerous synthetic reactions in nearly all living tissues makes the metabolic reactions of this compound of interest. Rapid hydrolysis to orthophosphate is presumed to be the fate of most inorganic pyrophosphate but the possibility of the conservation and utilization of some of the energy of this compound has been a su...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1960
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)64644-7